Compare · all pairs
A
PT-141
B
Sermorelin
A side-by-side look at what PT-141 and Sermorelin actually are, so you can see where they overlap and where they genuinely differ before deciding which is worth researching further — no score, no “winner,” just the facts next to each other.
FDA status
PT-141
FDA-approved — Vyleesi, for premenopausal HSDD only (the compounded version this board ranks is not FDA-reviewed)
Sermorelin
No current FDA-approved product — its only approved brand, Geref, is discontinued (not for safety or effectiveness reasons)
Typical dose / use
PT-141
Vyleesi's approved dose: 1.75 mg SC as needed, ≤8 doses/month (the compounded version has no agency-set dose)
Sermorelin
No current label — the historical approved dose was 30 µg/kg/day SC (pediatric growth-hormone deficiency, discontinued)
Product forms
PT-141
Injectable — Vyleesi ships as a pre-filled autoinjector; the compounded version is a reconstituted powder vial
Sermorelin
Injectable
How it works
PT-141
Activates melanocortin receptors — chiefly MC4R in the hypothalamus — believed to trigger dopamine release that increases sexual desire, a brain-mediated mechanism distinct from PDE5 inhibitors, which act on blood flow.
Sermorelin
Activates the GHRH receptor on the pituitary gland, stimulating the body's own pulsatile release of growth hormone rather than supplying growth hormone directly.
Providers ranked on this board
PT-141
7
Sermorelin
61
Cost on this board
PT-141
From $75/mo
Sermorelin
From $79/mo
Every fact above is reused from PT-141's and Sermorelin's own compound guides, not re-derived here. A highlighted value means that number is objectively larger or smaller — more providers ranked, a lower standing price — never a claim about which compound is “better.” Cost and provider counts are read live from each compound's own board and can change without notice.
Go deeper on each compound
PT-141
Medical disclaimer: This content is for general educational purposes only and is not medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional before starting, stopping, or changing any treatment.
This page is a fact comparison, not a recommendation for either compound — talk to a licensed clinician about your own situation.