Compare · all pairs
A
Semaglutide
B
Tirzepatide
A side-by-side look at what Semaglutide and Tirzepatide actually are, so you can see where they overlap and where they genuinely differ before deciding which is worth researching further — no score, no “winner,” just the facts next to each other.
We've already written the deeper comparison
The fact table below is a quick reference. For the full trial-by-trial argument — head-to-head results, not just facts side by side — read Tirzepatide vs. semaglutide: what the trials show.
FDA status
Semaglutide
FDA-approved — Wegovy & Ozempic (the compounded version this board ranks is not independently FDA-reviewed)
Tirzepatide
FDA-approved — Zepbound & Mounjaro (the compounded version this board ranks is not independently FDA-reviewed)
Typical dose / use
Semaglutide
0.25–2.4 mg/week (FDA label range)
Tirzepatide
2.5–15 mg/week (FDA label range)
Product forms
Semaglutide
Injectable; also an oral tablet (Wegovy)
Tirzepatide
Injectable
How it works
Semaglutide
Activates the GLP-1 receptor alone — one target, versus tirzepatide's two — slowing gastric emptying, boosting insulin release when blood sugar is high, and reducing appetite.
Tirzepatide
Activates two hormone receptors at once — GIP and GLP-1 — slowing gastric emptying, increasing insulin release when blood sugar is high, and reducing appetite.
Providers ranked on this board
Semaglutide
108
Tirzepatide
111
Cost on this board
Semaglutide
From $64/mo
Tirzepatide
From $79/mo
Every fact above is reused from Semaglutide's and Tirzepatide's own compound guides, not re-derived here. A highlighted value means that number is objectively larger or smaller — more providers ranked, a lower standing price — never a claim about which compound is “better.” Cost and provider counts are read live from each compound's own board and can change without notice.
Go deeper on each compound
Semaglutide
Medical disclaimer: This content is for general educational purposes only and is not medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional before starting, stopping, or changing any treatment.
This page is a fact comparison, not a recommendation for either compound — talk to a licensed clinician about your own situation.