Compare · all pairs
A
Sermorelin
B
Tesamorelin
A side-by-side look at what Sermorelin and Tesamorelin actually are, so you can see where they overlap and where they genuinely differ before deciding which is worth researching further — no score, no “winner,” just the facts next to each other.
We've already written the deeper comparison
The fact table below is a quick reference. For the full trial-by-trial argument — head-to-head results, not just facts side by side — read Sermorelin vs. tesamorelin: what the evidence shows.
FDA status
Sermorelin
No current FDA-approved product — its only approved brand, Geref, is discontinued (not for safety or effectiveness reasons)
Tesamorelin
FDA-approved — Egrifta SV & Egrifta WR, but only for reduction of excess abdominal fat in HIV-associated lipodystrophy, not weight loss or anti-aging; neither label covers the compounded version some providers sell
Typical dose / use
Sermorelin
No current label — the historical approved dose was 30 µg/kg/day SC (pediatric growth-hormone deficiency, discontinued)
Tesamorelin
1.4 mg (Egrifta SV) or 1.28 mg (Egrifta WR), SC once daily — the FDA label states the two formulations are not substitutable
Product forms
Sermorelin
Injectable
Tesamorelin
Injectable
How it works
Sermorelin
Activates the GHRH receptor on the pituitary gland, stimulating the body's own pulsatile release of growth hormone rather than supplying growth hormone directly.
Tesamorelin
A GHRH(1-44)-based analog that, per its own FDA label, binds and stimulates the same pituitary GHRH receptor as sermorelin's shorter GHRH(1-29) fragment, at similar potency to endogenous GHRH.
Providers ranked on this board
Sermorelin
67
Tesamorelin
Not a board molecule — Tesamorelin isn't sold as a compounded product by any provider on this site's ranked boards.
Cost on this board
Sermorelin
From $79/mo
Tesamorelin
Not a board molecule — Tesamorelin isn't sold as a compounded product by any provider on this site's ranked boards.
Every fact above is reused from Sermorelin's own compound guide and Tesamorelin's own research article, not re-derived here. A highlighted value means that number is objectively larger or smaller — more providers ranked, a lower standing price — never a claim about which compound is “better.” Cost and provider counts are read live from each compound's own board and can change without notice.
Go deeper on each compound
Sermorelin
Tesamorelin
Medical disclaimer: This content is for general educational purposes only and is not medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional before starting, stopping, or changing any treatment.
This page is a fact comparison, not a recommendation for either compound — talk to a licensed clinician about your own situation.