Head to head
Sesame Care vs PlushCare
What each one charges a month, which pharmacy each will name, and where each will treat you — read off their own sites, not their marketing.
Both sell compounded semaglutide, where our ranking places Sesame Care at #2 and PlushCare at #72 — on the criteria we publish.
What each actually charges
A blank means that provider does not sell that compound at all. Prices are the real month-to-month figure, not a prepay or first-month rate.
| Compound | SC Sesame Care | PL PlushCare |
|---|---|---|
| Tirzepatide | Doesn't sell it | $399/mo+ |
| Semaglutide | $249/mo | $149/mo+ |
| Pharmacy named | 503B facility | Not disclosed |
Sesame Care checked August 2026; PlushCare checked August 2026.
Who each one suits
Good fit if you can live with Sesame's refund caveat: message your provider after the first visit and you give up the refund.
The catch: Read Sesame's Refund Policy all the way through and the refund window narrows sharply for anyone who actually uses the service first: "Please note that we cannot offer full or partial refunds for our weight loss program if, after your initial visit, you have utilized other features of the service, such as provider messaging." Message your provider with a follow-up question — the exact thing the plan's "unlimited messaging" benefit invites — and the refund is gone. The other thing worth knowing: this same company's compounded tirzepatide is a different offering altogether. That flow is a book-a-provider marketplace ("Book with a top-rated provider of your choice through Sesame's weight loss program") where the page says "Cost of medication not included" and the prescription may be picked up "at a pharmacy near you." Anyone assuming the semaglutide deal — flat price, medication included, nationwide — describes the tirzepatide one would be wrong. On FDA warning letters: nothing turned up under "Sesame Care" or "Sesame, Inc." That is an absence, not a clearance.
Good fit if dose-tiered pricing disclosed directly on the product page, not gated behind a quiz matters to you.
The catch: PlushCare's homepage states, "Appointments are available in all 50 states," while its own compounded-tirzepatide page limits the compounded product specifically to a 38-state-plus-DC list — a real, same-company nationwide-vs-narrower contradiction a reader would only find by reading both pages. No FDA warning letter was found for "PlushCare" — checked directly, clean.
Where each one will treat you
Sesame Care
All 50. "Available in all 50 states" sits directly beneath the price on the compounded-semaglutide page, with nothing on that page contradicting it.
PlushCare
List published. PlushCare's own compounded-tirzepatide page limits the compounded product to a specific 38-state-plus-DC list — narrower than the "all 50 states" claim on its own homepage for general telehealth appointments.
Ready to start with one?
Any paid placement here is marked Partner and listed first, as a disclosed commercial position — within that group, and separately within every other row, every provider is still ranked on the criteria printed on this page, never anything else
Medical disclaimer: This content is for general educational purposes only and is not medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional before starting, stopping, or changing any treatment.